منابع مشابه
Drebrin shows self-restraint
Injured neurons pump up the volume A wounded axon sends out a long-distance distress signal. HuntworkRodriguez et al. uncovered a positive feedback loop that might amplify the alarm and help it spread along the axon. A damaged axon dispatches an alert to the cell body, which fi res up genes that— depending on the neuron’s location—trigger healing or cause the axon to degenerate and the cell to ...
متن کاملNervous Activity in a Stem Cell Niche
In this issue of Cell, report a new regulatory axis for the mobilization of hematopoietic stem cells that links these cells to the nervous system and bone in an unanticipated way. The new findings suggest that the nervous system, which has the inherent ability to integrate information from throughout the organism, may govern the local relationship between stem cells and their niches.
متن کاملRenal capsule as a stem cell niche.
Renal resident stem cells were previously reported within the renal tubules and papillary area. The aim of the present study was to determine whether renal capsules harbor stem cells and whether this pool can be recruited to the renal parenchyma after ischemic injury. We demonstrated the presence of label-retaining cells throughout the renal capsule, at a density of ∼10 cells/mm(2), and their c...
متن کاملThe hematopoietic stem cell niche.
Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells found within the highly specialized microenvironment termed the hematopoietic stem cell niche. Understanding and exploiting the HSC niche is a goal of basic scientists and cl...
متن کاملStem cell maintenance in a different niche
To overcome the difficulty of controlling stem cell fate and function in applications to regenerative medicine, a number of alternative approaches have been made. Recent reports demonstrate that a non-cellular niche modulating the biophysical microenvironment with chemical factors can support stem cell self-renewal. In our previous studies, early establishment was executed to optimize biophysic...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2094iti2